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Brian Pietrosimone, Ph.D.

Associate Professor, Department of Exercise and Sport Science
Adjunct Associate Professor, Department of Orthopaedics
Adjunct Associate Professor, Department of Allied Health

Contact Information:
Twitter: @BPietrosimone


Dr. Pietrosimone’s research focuses on understanding the multifaceted development of posttraumatic osteoarthritis following knee injuries. He is particularly interested in developing multimodal treatment strategies to prevent posttraumatic osteoarthritis in those who have sustained an anterior cruciate ligament injury. Dr. Pietrosimone has published over 160 peer-reviewed original research manuscripts and has lectured nationally and internationally on the research he has conducted with his team.

PubMed Link:

Previous Education
Ph.D., University of Virginia, 2009
M.Ed., University of Virginia, 2006
B.S., Springfield College, 2005

Awards and Honors
Fellow, American College of Sports Medicine. 2017
Freddie Fu New Investigator Award. National Athletic Trainers’ Association Research and Education Foundation. 2015
Excellence in Undergraduate Teaching. Department of Exercise and Sport Science, University of North Carolina at Chapel Hill. 2015

Lab Video:


The Team


Caroline Lisee, Ph.D., ATC
Post-Doctoral Research Associate

Educational Background:
B.S.      Ithaca College
M.Ed.   University of Virginia
Ph.D.    Michigan State University


Contact Information:
Twitter: @CarolineLisee

Pubmed: Caroline Lisee

Caroline’s primary research interests are to identify modifiable aspects of joint mechanical loading and develop evidence-based interventions to maintain knee joint health, reduce disability, and improve quality of life in individuals with a history of ACL injury and ACLR. Caroline hopes to accomplish this goal by bridging the gap between clinical and free-living assessment of mechanical loading behavior of patients through the application of biomechanics and wearable sensors to prevent the onset or slow the progression of post-traumatic osteoarthritis.

PubMed Link:



Alyssa Evans-Pickett, M.S.  

Doctoral Student

Educational Background:
B.S.      Brigham Young University
M.S.     Brigham Young University

Contact Information:
Twitter: @alyssa7evans


Working under the direction of Dr. Brian Pietrosimone, she conducts research in the area of knee biomechanics and biochemistry, with special interests in post-traumatic osteoarthritis. She is a registered member of the American College of Sports Medicine (ACSM) and Osteoarthritis Research Society International (OARSI).



Elizabeth Bjornsen, M.S.  
Doctoral Student

B.S. Taylor University
M.S. University of Arkansas

Contact Information:


Elizabeth’s previous work utilized data analytics to highlight the interdisciplinary and collaborative nature of the exercise science field. Current research interests lie in understanding biomechanical outcomes following ACL injury and the development of post-traumatic osteoarthritis.


Undergraduate Research Assistants:


Cassidy Kershner  ’21

Cassidy is a senior, undergraduate student double majoring in biology and neuroscience. In her free time, Cassidy enjoys playing field hockey and going on hikes.


Lab Group Alumni

Brittney Luc-Harkey PhD, Clinical Research Manager, Neurological Clinical Research Institute, Massachusetts General Hospital. Graduated 2017.

Matthew Harkey PhD, Assistant Professor, Department of Kinesiology, Michigan State University. Graduated 2017.

Hope Davis-Wilson PhD, Post-Doctoral Fellow, Interdisciplinary Movement Science Lab, University of Colorado Anschutz Medical Campus. Graduated 2020.

Steven Pfeiffer PhD, Assistant Professor, School of Applied Health and Wellness, Ohio University. Graduated 2020.

Current Grant Funding & Research Projects

Biomechanical Changes Following ACL Injury that Influence the Development of Posttraumatic Osteoarthritis (Principal Investigator), Awarded by the Arthritis Foundation. 2020-2023

Effect of ZILRETTA Injection on neuromuscular function, gait biomechanics and physical performance (Principal Investigator), Investigator Initiated Clinical Study Grant Awarded by Flexion Therapeutics. 2020-2022

Effect of Knee Bracing on Improving Pain & Disability, Physical Performance, Physical Activity and Femoral Cartilage Deformation in Individuals with Medial Compartment Knee Osteoarthritis (Principal Investigator), Awarded by American Orthotic & Prosthetic Association. 2018-2020.

In Vivo Manipulation of Mechanical Loading: Using Real-Time Biofeedback to Strategically Understand the Acute Biomechanical, Biochemical and Structural Changes induced by Lower Extremity Joint Loading (Co-Principal Investigator), Awarded by National Institutes of Health. 2020-2023

Effect of Skeletal Maturity on Biomarkers for Post- traumatic OA after ACL Injury (Co-Principal Investigator), Awarded by North Carolina Translational and Clinical Sciences Institute. 2020-2022

Preventing Incident Knee Osteoarthritis: The Osteoarthritis Prevention Study (TOPS) (Co-Investigator), Awarded by National Institutes of Health. 2020-2022